In these times, healthcare systems and the economy down to the grassroots of our society are tremendously challenged. However, we must also look to the future and make strong progress in the world of medical research and experimental science in cartilage repair and joint preservation. The ICRS mission of advancing science and education in the treatment of musculoskeletal disorders is an enduring goal and will remain even after we have - hopefully - overcome this viral catastrophe. We look forward to welcoming you all healthy and strong to Berlin for the 16th ICRS World Congress, August 23-26, 2021. We are planning the scientific program with the aim to focus on current developments in our field and to report, discuss and analyze them among scientists and clinical researchers as well as orthopaedic surgeons, health care providers and - last but not least - industry, thus presenting the economic background of all our efforts.